Publications



Ishikawa T. (2020) Saccharomyces cerevisiae in neuroscience – how unicellular organism helps to better understand prion protein? Neural Regen. Res., accepted for publication.

Ishikawa T.
, Lisiecki K. (2020) Anti-prion drug screening system in Saccharomyces cerevisiae based on an artificial [LEU2+] prion. Fungal Genet. Biol., 134:103280. [Publisher's site]

Szpila M., Walewska A., Sabat D.K., Strączyńska P., Ishikawa T., Milewski R., Szczepańska K., Ajduk A. (2019) Postovulatory ageing modifies sperm-induced Ca2+ oscillations in mouse oocytes through a conditions-dependent, multi-pathway mechanism. Sci. Rep., 9:11859. [PDF]

Girstun A., Ishikawa T., Staroń K. (2019) Effects of SRSF1 on subnuclear localization of topoisomerase I. J. Cell. Biochem., 120(7):11794-11808. [Publisher's site]

Fluks M., Szczepańska K., Ishikawa T., Ajduk A. (2019) Transcriptional status of mouse oocytes corresponds with their ability to generate Ca2+ release. Reproduction, 157(5):465-474. [Publisher's site]

Fluks M., Salas K., Szczepańska K., Ishikawa T., Ajduk A. (2019) Don't stop me now. Oocytes need to finish transcription to ensure correct regulation of Ca2+ homeostasis. FEBS Open Bio, 9(S1):25-26. [PDF]

Kwiatkowski S., Seliga A.K., Veiga-da-Cunha M., Vertommen D., Terreri M., Ishikawa T., Grabowska I., Jagielski A.K., Drozak J. (2018) SETD3 protein is the actin-specific histidine N-methyltransferase. eLife, 7:e37921. [PDF]

Kwiatkowski S., Seliga A.K., Terreri M., Ishikawa T., Grabowska I., Jagielski A.K., Drozak J. (2018) Preliminary characterization of SET domain containing protein 3 (SETD3) as actin-specific histidine N-methyltransferase. FEBS Open Bio, 8(S1):236. [PDF]

Dass R., Grudziąż K., Ishikawa T., Nowakowski M., Dębowska R., Kazimierczuk K. (2017) Fast 2D NMR spectroscopy for in vivo monitoring of bacterial metabolism in complex mixtures. Front. Microbiol., 8:1306. [PDF]

Trepczyński M., Ishikawa T. (2017) Czy kobieta to niewydarzony mężczyzna? Metafizyka płci z perspektywy Tomasza z Akwinu i dzisiejszej biologii. Przegląd Filozoficzny, 2/2017(102):237-254. [PDF]

Girstun A., Ishikawa T., Kowalska-Loth B., Czubaty A., Staroń K. (2017) Subnuclear localization of human topoisomerase I. J. Cell. Biochem., 118(2):407-419. [Publisher's site]

Milanowski R., Gumińska N., Karnkowska A., Ishikawa T., Zakryś B. (2016) Intermediate introns in nuclear genes of euglenids - are they a distinct type? BMC Evol. Biol., 16(1):49. [PDF]

Ishikawa T.
(2014) Prawda czy fałsz? Treści naukowe w środkach masowego przekazu. Edukacja Biologiczna i Środowiskowa, S1(51):70-74. [Flash]

Milanowski R., Karnkowska A., Ishikawa T., Zakryś B. (2014) Distribution of conventional and non-conventional introns in tubulin (α and β) genes of euglenids. Mol. Biol. Evol., 31(3):584-593. [PDF]

Ishikawa T., Krzysko K.A., Kowalska-Loth B., Skrajna A.M., Czubaty A., Girstun A., Cieplak M.K., Lesyng B., Staron K. (2012) Activities of topoisomerase I in the complex with SRSF1. Biochemistry, 51(8):1803-1816. [Publisher's site]

Ishikawa T., Czubaty A., Staroń K. (2009) Linker engineering of SF2/ASF splicing factor switches enzymatic activities of human topoisomerase I. Acta Biochem. Pol., 56(suppl1):44-45.

Cena A., Kozlowska E., Plochocka D., Grynberg M., Ishikawa T., Fronk J., Kurlandzka A. (2008) The F658G substitution in Irr1/Scc3 cohesin of Saccharomyces cerevisiae is semi-dominant in the diploid and disturbs mitosis, meiosis and the cell cycle. Eur. J. Cell Biol., 87(10):831-844. [Publisher's site]

Trzcinska-Danielewicz J., Ishikawa T., Micialkiewicz A., Fronk J. (2008) Yeast transcription factor Oaf1 forms homodimer and induces some oleate-responsive genes in absence of Pip2. Biochem. Biophys. Res. Commun., 374(4):763-766. [Publisher's site]

Ishikawa T. (2008) Recent advances of research on the [PSI+] prion in Saccharomyces cerevisiae. Mycoscience, 49(4):221-228. [Publisher's site]

Bulkowska U., Ishikawa T., Kurlandzka A., Trzcinska-Danielewicz J., Derlacz R.A., Fronk J. (2007) Expression of murine DNA methyltransferases Dnmt1 and Dnmt3a in the yeast Saccharomyces cerevisiae. Yeast, 24(10):871-882. [PDF]

Ishikawa T. (2007) New aspects of research upon the yeast Saccharomyces cerevisiae [PSI+] prion. Postepy Biochem., 53(2):182-187. [PDF]


Invited talks



Ishikawa T. (2019) How does microbiome affects the human body?, Żywienie bez Granic, Warszawa, Poland, June 1, 2019

Ishikawa T.
(2019) An introduction to bioeconomics, Poznań, Poland, March 16, 2019

Ishikawa T. (2018) Antisense anticipations, Cultures of anticipated future, Institute of Polish Culture, Warsaw, Poland, October 12, 2018

Ishikawa T.
(2018) Prion proteins of Saccharomyces cerevisiae – physiological functions and their implementation in biomedical research, BioOpen, Łodź, Poland, May 25, 2018

Ishikawa T.
(2018) An introduction to bioeconomics, Poznań, Poland, March 17, 2018

Ishikawa T.
(2017) Polish biotech innovation - How one atom modification can lead to new therapy? Code4Life, Roche Diagnostics Polska, Warsaw, Poland, October 27, 2017

Ishikawa T. (2017) An introduction to bioeconomics, Poznań, Poland, March 4, 2017

Ishikawa T.
(2016) An introduction to bioeconomics, Poznań, Poland, March 5, 2016

Ishikawa T. (2013) True or false? Scientific issues in mass media. Biology Teachers Conference, Poznań, Poland, September 25, 2013

Ishikawa T. (2013) How shape of protein influences our life? Scientific Conference of Children on the Brain, Moscow, Russia, April 7, 2013

Ishikawa T. (2012) Will DNA yet surprise us? Intercollegiate Symposium on Biotechnology "Symbiosis", Warsaw, Poland, May 26, 2012

Ishikawa T. (2011) Structural determinants for the protein substrates of the kinase activity of topoisomerase I. Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Japan, May 19, 2011

Ishikawa T. (2009) Insights into the biological meaning of prions. Meeting of Polish Association of Neuropathologists, Warsaw, Poland, November 13, 2009


Conference communications



Adamiec M., Misztala L., Kosicka E., Ishikawa T., Paluch-Lubawa E., Luciński R. (2019) Egy2-dependent intramembrane proteolysis may regulate expression of some PEP-transcribed chloroplast genes in Arabidopsis thaliana. 9th Conference of Polish Society of Experimental Plant Biology, Toruń, Poland, September 9-12, 2019

Grudziąż K., Ishikawa T., Koźmiński W. (2019) Interaction of the disordered regions of MeCP2 with DNA. EUROISMAR 2019, Freie Universität Berlin, Berlin, Germany, August 25-30, 2019

Ishikawa T. (2019) Making the impossible possible: the metamorphosis of Polish Biology Olympiad. 30th International Biology Olympiad, Educational Session, Szeged, Hungary, July 14-21, 2019

Ishikawa T.
, Prażmo E. (2018) Release and glow: application of split green fluorescent protein to anti-prion drug screening system in Saccharomyces cerevisiae, 41st annual meeting of the Molecular Biology Society of Japan, Yokohama, Japan, November 28-30, 2018

Grudziąż K., Ishikawa T., Żerko S., Górka M.J., Koźmiński W. (2018) NMR studies of full-length MeCP2 interaction with DNA, 41st annual meeting of the Molecular Biology Society of Japan, Yokohama, Japan, November 28-30, 2018

Grudziąż K., Ishikawa T., Żerko S., Górka M.J., Koźmiński W. (2018) NMR studies of full-length MeCP2 interaction with DNA, 10th Symposium: Nuclear magnetic resonance in chemistry, physics and biological sciences, Warsaw, Poland, September 26-28, 2018

Kwiatkowski S., Seliga A.K., Ishikawa T., Grabowska I., Jagielski A., Drożak J. (2018) Preliminary characterization of SET domain containing protein 3 (SETD3) as actin-specific histidine N-methyltransferase, FEBS Congress, Prague, Czech Republic, 7-12 July, 2018

Grudziąż K., Ishikawa T., Żerko S., Górka M., Koźmiński W. (2018) NMR studies of full-length MeCP2 interaction with DNA, Gordon Research Conference on Intrinsically Disordered Proteins, Les Diablerets, Switzerland, July 1-6, 2018

Grudziąż K., Żerko S., Frieske D., Górka M., Ishikawa T., Koźmiński W. (2017) Application of high-dimensional methods to resonance assignment of MeCP2. Bridging solution methods: from NMR to X-ray scattering and biophysics, Patras, Greece, September 18-22, 2017

Siporska A., Ishikawa T. (2017) NSN na UW – Niezwykła Szkoła Naukowa Chemiczno-Biologiczna na UW. 60. Zjazd Naukowy Polskiego Towarzystwa Chemicznego, Wrocław, Poland, September 17-21, 2017

Grudziąż K., Górka M.J., Frieske D., Ishikawa T., Koźmiński W. (2017) NMR studies of human MeCP2 – large protein with long disordered regions. EUROMAR2017 – European Congress on Magnetic Resonance, Warsaw, Poland, July 2-6 2017

Girstun A., Ishikawa T., Staroń K. (2017) Effects of SR proteins on subnuclear distribution of topoisomerase I. 4D Nucleome: The Cell Nucleus in Space and Time, Kraków, Poland, May 14-17, 2017

Woźniak A., Ishikawa T., Leś A. (2017) Modelowanie molekularne procesu strukturalizacji białka SECISBP2 w obecności fragmentu mRNA. XIX sesja użytkowników ICM UW, Warsaw, Poland, April 19-21, 2017

Grudziąż K., Sztyler A., Przygońska K., Koźmiński W., Ishikawa T. (2016) NMR studies of unstructured fragment of human topoisomerase I. 39th annual meeting of the Molecular Biology Society of Japan, Yokohama, Japan, November 30 - December 2, 2016

Sztyler A., Przygońska K., Szewczyk M., Grudziąż K., Ishikawa T. (2016) The quest for a key features of the kinase activity of human topoisomerase I: characterization of interacting domains of topoisomerase I and SRSF1 splicing factor. 39th annual meeting of the Molecular Biology Society of Japan, Yokohama, Japan, November 30 - December 2, 2016

Dass R., Grudziąż K., Ishikawa T., Kazimierczuk K. (2016) Application of NUS to monitor in vivo processes. 9th Symposium Nuclear Magnetic Resonance in chemistry, physics and biological sciences, Warsaw, Poland, September 28-30, 2016

Grudziąż K., Sztyler A., Przygońska K., Koźmiński W., Ishikawa T. (2016) Role of the unstructured fragment of human topoisomerase I in kinase activity. Bio2016 Congress, Wrocław, Poland, September 13-16, 2016

Dass R., Grudziąż K., Ishikawa T., Kazimierczuk K. (2016) Application of NUS to monitor in vivo processes. SMASH 2016 small molecule NMR conference, La Jolla, California, USA, September 11-14, 2016

Szpila M., Kiełbasa A., Sabat D.K., Ishikawa T., Szczepańska K., Ajduk A. (2016). Postovulatory aging deregulates sperm-induced Ca2+ oscillations in mouse oocytes. Development of Scientific Cooperation in Reproductive Medicine Research III, Warsaw, Poland, June 10-11, 2016

Ishikawa T.
, Kruszyńska D., Szewczyk M. (2015). Evaluation of anti-prion drugs by Saccharomyces cerevisiae expressing artificial prion. EMBO Young Scientists Forum, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland, July 2-3, 2015

Ishikawa T., Lisiecki K. (2014). Anti-prion drug screening system based on artificial prions in Saccharomyces cerevisiae. 37th annual meeting of the Molecular Biology Society of Japan, Yokohama, Japan, November 25-27, 2014

Grudziąż K., Szewczyk M., Ishikawa T. (2014). How to find active site of topoisomerase I acting as kinase? 37th annual meeting of the Molecular Biology Society of Japan, Yokohama, Japan, November 25-27, 2014

Ishikawa T., Szewczyk M., Banerjee S., Grudziąż K., Staroń K. (2013). Topoisomerase I as a kinase of splicing factors. 36th annual meeting of the Molecular Biology Society of Japan, Kobe, Japan, December 3-6, 2013

Milanowski R., Karnkowska A., Pałczyńska N., Ishikawa T., Zakryś B. (2013). Do intermediate introns in nuclear genes of euglenids really exist? 54th meeting of Czech Phycological Society, Trebon, Czech Republic, September 16-18, 2013

Milanowski R., Karnkowska A., Ishikawa T., Zakryś B. (2013) Toward a model of euglenoid non-conventional introns structure. 43rd Jirovec’s Protozoological Days by Czech Society for Parasitology, Tyn nad Vltavou, Czech Republic, May 6-10, 2013

Ishikawa T., Grudziąż K., Rokosz K., Skrajna A.M., Bukowicki M., Banerjee S., Staroń K. (2012) Phosphorylation of splicing factors: the curious case of topoisomerase I (acting as a kinase). Polish-German Biochemical Societies Joint Meeting, Poznań, Poland, September 11-14, 2012

Krzyśko K.A., Skrajna A.M., Ishikawa T., Grudziąż K., Rokosz K., Lesyng B., Staroń K. (2012) Dual activity of human topoisomerase I and its interactions with SRSF1. 7th International Conference "Inhibitors of Protein Kinases", Warsaw, Poland, August 24-27, 2012

Milanowski R., Karnkowska-Ishikawa A., Boulahdjel A., Ishikawa T., Zakrys B. (2012) Distribution of conventional and non-conventional introns in tubA and tubB genes of euglenoids. Protist 2012, Oslo, Norway, July 29 - August 3, 2012

Grudziąż K., Ishikawa T. (2012) Determinanty strukturalne białek substratowych dla ludzkiej topoizomerazy I w aktywności kinazowej. Międzyuczelniane Sympozjum Biotechnologiczne „Symbioza”, Warsaw, Poland, May 25-27, 2012

Skrajna A.M., Ishikawa T., Krzysko K.A., Kowalska-Loth B., Lesyng B., Staron K. (2011) Where modelling meets molecular biology: the complex of topoisomerase I and ASF/SF2. Multi-Pole Approach to Structural Biology Conference, Warsaw, Poland, November 16-19, 2011

Ishikawa T., Krzysko K.A., Skrajna A., Cieplak M., Czubaty A., Lesyng B., Staron K. (2011) To be or not to by (phosphorylated): key features of SR proteins important for selective phosphorylation by topoisomerase I. 22nd Wilhelm Bernhard Nuclear Workshop, Riga, Latvia, August 25-30, 2011

Ishikawa T., Skrajna A., Krzysko K.A., Cieplak M., Czubaty A., Lesyng B., Staron K. (2011) Structural determinants for the protein substrates of the kinase activity of topoisomerase I. EMBO Young Scientists Forum, International Institute Of Molecular And Cell Biology, Warsaw, Poland, June 30 - July 1, 2011

Skrajna A., Del Carmen Boyano Adanez M., Lopez P.S., Trzcinska-Danielewicz J., Ishikawa T., Staron K. (2010) Induction of apoptosis in cancer cells. II International Conference of Biotechnology Students, Wroclaw, Poland, November 19-21, 2010

Ishikawa T., Kowalska-Loth B., Czubaty A., Krzysko K.A., Studzian M., Staron K. (2009) Switching of mutually exclusive enzymatic activities controlled by peptide linker: the case of human topoisomerase I. 21st Wilhelm Bernhard Nuclear Workshop, Ustron, Poland, August 31 - September 4, 2009

Girstun A., Kowalska-Loth B., Ishikawa T., Kozlowski P., Szwedziak P., Staron K. (2009) Linker domain regulates subnuclear distribution of human topoisomerase I. 21st Wilhelm Bernhard Nuclear Workshop, Ustron, Poland, August 31 - September 4, 2009

Studzian M., Czubaty A., Ishikawa T., Staron K. (2009) UP1, functional fragment of heterogeneous nuclear ribonucleoprotein A1 changes a pattern of phosphorylation of SR proteins in HeLa cells, International Life Science Students' Conference, Kyiv, Ukraine, August 19-23, 2009

Ishikawa T., Czubaty A., Staron K. (2009) Linker engineering of SF2/ASF splicing factor switches enzymatic activities of human topoisomerase I. 6th International Conference Inhibitors of Protein Kinases, Warsaw, Poland, June 27 - July 1, 2009

Ishikawa T., Czubaty A., Kowalska-Loth B., Girstun A., Staron K. (2008) Molecular switch of enzymatic activities: the case of topoisomerase I. 12th Gliwice Scientific Meetings, Comprehensive Cancer Centre Maria Sklodowska-Curie Memorial Institute Branch Gliwice, Poland, November 21-22, 2008

Ishikawa T., Trzcinska-Danielewicz J., Bulkowska U., Micialkiewicz A., Jacewicz A., Brewczynski K., Fronk J. (2007) Chromatin structure of oleate-responsive genes in the yeast Saccharomyces cerevisiae. EMBO Conference on Chromatin and Epigenetics, EMBL Heidelberg, Germany, May 3-6, 2007
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